Tehran University Medical Journal (Jul 2002)
Comparison of Anti-CMV (IgG, IgM) Prevelence and Serum p2-MG (Beta-2 Microglobulin) in Heomodialysed Patients and Blood Donors
Abstract
CMV belongs to herpes viridea family and it is the largest human virus. Prevalence of CMV depends on age, race, geographic and socioeconomic factors. CMV infection has been a recognized complication of transfusion for about three decades, in an immature or compromised immune system situation. If a transplant candidate has not been infected with CMV and no CMV specific antibodies can be detected by serology, a primary infection could be transmitted via transfusion or transplantation. Patient who are under dialysis are susceptible to CMV infection, in addition of increase serum levels of p2-MG(Beta-2 Microglobulin)."nMaterials and Methods: we detected anti CMV (IgM -IgG) antibodies for 128 renal transplant candidates who were under intermittent heamodialysis and 1040 blood donors, as controls and compared serum p2-MG levels in 48 of the patients with 35 controls with ELISA technique. For 15 patients, R5 (Cuprophan) and for 7 patients S2 (Polysulphone) filters were used."nResults: Our data showed:"n1-90 percent of normal blood donors and 89.8 percent of the patients were IgG positive. Statistical analysis showed no significant difference between these two groups (pO.Ol). This reflected high prevalence of CMV ."n2- 0.2 percent of normal individuals and 2.3 percent of the patients were positive for IgM. There was significant difference in IgM between these two groups (p<0.01)."n3- p2-MG levels in patient group were elevated and there was a significant differences between two groups (P <0.05 ) and no differences between common used dialysis filter in this study.
