SOMATOFORM DYSFUNCTION OF THE AUTONOMIC NERVOUS SYSTEM IN ADOLESCENTS: VEGETATIVE HOMEOSTASIS AND ERYTHROCYTE MEMBRANE REACTIVITY

Abstract

Aim. To study autonomic homeostasis and reactivity of erythrocyte membranes to bioregulators of the autonomic nervous system in adolescents with somatoform dysfunction of the autonomic nervous system to predict the course of the disease and assess adaptive capabilities. Materials and methods. Clinical, instrumental and laboratory examination of adolescents with somatoform dysfunction of the autonomic nervous system and healthy adolescents was carried out. Results. In adolescents with somatoform dysfunction of the autonomic nervous system, dysregulatory types of autonomic response were revealed at the level of erythrocyte membranes. Significant biophysical risk factors for the paroxysmal course of the disease have been identified: low peak and rate fluorescence values with acetylcholine, as well as low peak fluorescence values with adrenaline. Conclusion. Identification of autonomic dysregulation at the level of cell membranes in adolescents with somatoform dysfunction of the autonomic nervous system is an important factor determining the course of the disease, as well as the adaptive capabilities of the adolescent’s body. Establishment of significant membrane risk factors for a complicated course of the disease is necessary for a personalized approach to the implementation of therapeutic and prophylactic measures.

Keywords

• adolescents
• somatoform dysfunction
• autonomic nervous system
• autonomic homeostasis
• reactivity of erythrocyte membranes