The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

Kazuhiko Yamamura; Takehito Uruno; Akira Shiraishi; Yoshihiko Tanaka; Miho Ushijima; Takeshi Nakahara; Mayuki Watanabe; Makiko Kido-Nakahara; Ikuya Tsuge; Masutaka Furue; Yoshinori Fukui

doi:10.1038/ncomms13946

Nature Communications (Jan 2017)

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

Kazuhiko Yamamura,
Takehito Uruno,
Akira Shiraishi,
Yoshihiko Tanaka,
Miho Ushijima,
Takeshi Nakahara,
Mayuki Watanabe,
Makiko Kido-Nakahara,
Ikuya Tsuge,
Masutaka Furue,
Yoshinori Fukui

Affiliations

Kazuhiko Yamamura: Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University
Takehito Uruno: Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University
Akira Shiraishi: Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University
Yoshihiko Tanaka: Department of Functional Bioscience, Section of Infection Biology, Fukuoka Dental College
Miho Ushijima: Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University
Takeshi Nakahara: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
Mayuki Watanabe: Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University
Makiko Kido-Nakahara: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
Ikuya Tsuge: Department of Pediatrics, School of Medicine, Fujita Health University
Masutaka Furue: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
Yoshinori Fukui: Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University

DOI: https://doi.org/10.1038/ncomms13946
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+T cells, thus driving skin inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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