Nature Communications (Aug 2019)
Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids
- N. Alcala,
- N. Leblay,
- A. A. G. Gabriel,
- L. Mangiante,
- D. Hervas,
- T. Giffon,
- A. S. Sertier,
- A. Ferrari,
- J. Derks,
- A. Ghantous,
- T. M. Delhomme,
- A. Chabrier,
- C. Cuenin,
- B. Abedi-Ardekani,
- A. Boland,
- R. Olaso,
- V. Meyer,
- J. Altmuller,
- F. Le Calvez-Kelm,
- G. Durand,
- C. Voegele,
- S. Boyault,
- L. Moonen,
- N. Lemaitre,
- P. Lorimier,
- A. C. Toffart,
- A. Soltermann,
- J. H. Clement,
- J. Saenger,
- J. K. Field,
- M. Brevet,
- C. Blanc-Fournier,
- F. Galateau-Salle,
- N. Le Stang,
- P. A. Russell,
- G. Wright,
- G. Sozzi,
- U. Pastorino,
- S. Lacomme,
- J. M. Vignaud,
- V. Hofman,
- P. Hofman,
- O. T. Brustugun,
- M. Lund-Iversen,
- V. Thomas de Montpreville,
- L. A. Muscarella,
- P. Graziano,
- H. Popper,
- J. Stojsic,
- J. F. Deleuze,
- Z. Herceg,
- A. Viari,
- P. Nuernberg,
- G. Pelosi,
- A. M. C. Dingemans,
- M. Milione,
- L. Roz,
- L. Brcic,
- M. Volante,
- M. G. Papotti,
- C. Caux,
- J. Sandoval,
- H. Hernandez-Vargas,
- E. Brambilla,
- E. J. M. Speel,
- N. Girard,
- S. Lantuejoul,
- J. D. McKay,
- M. Foll,
- L. Fernandez-Cuesta
Affiliations
- N. Alcala
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- N. Leblay
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- A. A. G. Gabriel
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- L. Mangiante
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- D. Hervas
- Health Research Institute La Fe, Avenida Fernando Abril Martorell, Torre 106 A 7planta
- T. Giffon
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- A. S. Sertier
- Synergie Lyon Cancer, Centre Léon Bérard, 28 Rue Laennec
- A. Ferrari
- Synergie Lyon Cancer, Centre Léon Bérard, 28 Rue Laennec
- J. Derks
- Maastricht University Medical Centre (MUMC), GROW School for Oncology and Developmental Biology, P.O. Box 5800
- A. Ghantous
- International Agency for Research on Cancer (IARC/WHO), Section of Mechanisms of Carcinogenesis, 150 Cours Albert Thomas
- T. M. Delhomme
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- A. Chabrier
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- C. Cuenin
- International Agency for Research on Cancer (IARC/WHO), Section of Mechanisms of Carcinogenesis, 150 Cours Albert Thomas
- B. Abedi-Ardekani
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- A. Boland
- Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, 2 rue Gaston Crémieux, CP 5706
- R. Olaso
- Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, 2 rue Gaston Crémieux, CP 5706
- V. Meyer
- Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, 2 rue Gaston Crémieux, CP 5706
- J. Altmuller
- Cologne Centre for Genomics (CCG) and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Weyertal 115
- F. Le Calvez-Kelm
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- G. Durand
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- C. Voegele
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- S. Boyault
- Translational Research and Innovation Department, Cancer Genomic Platform, 28 Rue Laennec
- L. Moonen
- Maastricht University Medical Centre (MUMC), GROW School for Oncology and Developmental Biology, P.O. Box 5800
- N. Lemaitre
- Institute for Advanced Biosciences, Site Santé, Allée des Alpes
- P. Lorimier
- Institute for Advanced Biosciences, Site Santé, Allée des Alpes
- A. C. Toffart
- Pulmonology—Physiology Unit, Grenoble Alpes University Hospital
- A. Soltermann
- Institute of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstrasse 12
- J. H. Clement
- Department Hematology and Medical Oncology, Jena University Hospital, Am Klinikum 1
- J. Saenger
- Bad Berka Institute of Pathology, Robert-Koch-Allee 9
- J. K. Field
- Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 6 West Derby Street
- M. Brevet
- Pathology Institute, Hospices Civils de Lyon, University Claude Bernard Lyon 1, 59 Boulevard Pinel
- C. Blanc-Fournier
- CLCC François Baclesse, 3 avenue du Général Harris
- F. Galateau-Salle
- Department of Pathology, Centre Léon Bérard, 28, rue Laennec
- N. Le Stang
- Department of Pathology, Centre Léon Bérard, 28, rue Laennec
- P. A. Russell
- St. Vincent’s Hospital and University of Melbourne, Victoria Parade, Fitzroy
- G. Wright
- St. Vincent’s Hospital and University of Melbourne, Victoria Parade, Fitzroy
- G. Sozzi
- Pathology Division Fondazione, IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1
- U. Pastorino
- Pathology Division Fondazione, IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1
- S. Lacomme
- Nancy Regional University Hospital, CHRU, CRB BB-0033-00035, INSERM U1256, 29 Avenue du Maréchal de Lattre de Tassigny
- J. M. Vignaud
- Nancy Regional University Hospital, CHRU, CRB BB-0033-00035, INSERM U1256, 29 Avenue du Maréchal de Lattre de Tassigny
- V. Hofman
- Laboratory of Clinical and Experimental Pathology, FHU OncoAge, Nice Hospital, Biobank BB-0033-00025, IRCAN Inserm U1081 CNRS 7284, University Côte d’Azur, 30 avenue de la voie Romaine, CS
- P. Hofman
- Laboratory of Clinical and Experimental Pathology, FHU OncoAge, Nice Hospital, Biobank BB-0033-00025, IRCAN Inserm U1081 CNRS 7284, University Côte d’Azur, 30 avenue de la voie Romaine, CS
- O. T. Brustugun
- Drammen Hospital, Vestre Viken Health Trust, Vestre Viken HF, Postboks 800
- M. Lund-Iversen
- Institute of Cancer Research, Oslo University Hospital, Ullernchausseen 70
- V. Thomas de Montpreville
- Marie Lannelongue Hospital, 133 avenue de la Resistance
- L. A. Muscarella
- Fondazione IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1
- P. Graziano
- Fondazione IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1
- H. Popper
- Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6
- J. Stojsic
- Department of Thoracopulmonary Pathology, Service of Pathology, Clinical Center of Serbia, Pasterova 2
- J. F. Deleuze
- Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, 2 rue Gaston Crémieux, CP 5706
- Z. Herceg
- International Agency for Research on Cancer (IARC/WHO), Section of Mechanisms of Carcinogenesis, 150 Cours Albert Thomas
- A. Viari
- Synergie Lyon Cancer, Centre Léon Bérard, 28 Rue Laennec
- P. Nuernberg
- Cologne Centre for Genomics (CCG) and Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Weyertal 115
- G. Pelosi
- Department of Oncology and Hemato-Oncology, University of Milan, and Inter-Hospital Pathology Division, IRCCS Multimedica, Via Gaudenzio Fantoli, 16/15
- A. M. C. Dingemans
- Maastricht University Medical Centre (MUMC), GROW School for Oncology and Developmental Biology, P.O. Box 5800
- M. Milione
- Pathology Division Fondazione, IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1
- L. Roz
- Pathology Division Fondazione, IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1
- L. Brcic
- Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6
- M. Volante
- Department of Oncology, University of Turin, Pathology Division, Via Santena 7
- M. G. Papotti
- Department of Oncology, University of Turin, Pathology Division, Via Santena 7
- C. Caux
- Department of Immunity, Virus, and Inflammation, Cancer Research Centre of Lyon (CRCL), 28 Rue Laennec
- J. Sandoval
- Health Research Institute La Fe, Avenida Fernando Abril Martorell, Torre 106 A 7planta
- H. Hernandez-Vargas
- Cancer Research Centre of Lyon (CRCL), Inserm U 1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, 28 Rue Laennec
- E. Brambilla
- Institute for Advanced Biosciences, Site Santé, Allée des Alpes
- E. J. M. Speel
- Maastricht University Medical Centre (MUMC), GROW School for Oncology and Developmental Biology, P.O. Box 5800
- N. Girard
- Institut Curie, 26 Rue d’Ulm
- S. Lantuejoul
- Synergie Lyon Cancer, Centre Léon Bérard, 28 Rue Laennec
- J. D. McKay
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- M. Foll
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- L. Fernandez-Cuesta
- International Agency for Research on Cancer (IARC/WHO), Section of Genetics, 150 Cours Albert Thomas
- DOI
- https://doi.org/10.1038/s41467-019-11276-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 21
Abstract
The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Here, Alcala and colleagues present a multi-omics analysis of these tumours, revealing distinct molecular and prognostic subgroups.
