Hemostasis Disturbances in Patients in the Acute Period of Isolated Traumatic Brain Injury (Review)

Abstract

Acute isolated traumatic brain injury (TBI) is frequently associated with occurrence of hemostasis disorders, which may be accompanied with hemorrhagic and ischemic events in the brain matter, hence, normal functioning of the blood coagulation system is critical. Understanding of the pathophysiological mechanisms of this phenomenon might help adequate prophylaxis of secondary brain damage. Earlier, development of disseminated intravascular coagulation syndrome (DIC) has been generally considered as a mechanism of coagulation disorders during TBI. However, over the recent decades, new data emerged concerning the key role of tissue factor, systemic inflammation response, thrombocytopathy, protein C effect in the occurrence of this coagulopathy. This overview of literature is aimed at providing the new data on specific pathophysiological mechanisms underlying coagulopathy following TBI.

Keywords

• tbi-associated coagulopathy
• tbi
• traumatic brain injury
• hemostasis
• coagulopathy
• hemorrhagic foci
• ischemic foci
• platelet disfunction, microthrombs
• microvesicles
• tissue factor
• neurosurgery