Estimation The Level of Superoxide Dismutase 1 Among Iraqi Patients with Hypertension

Abstract

Background: Hypertension plays a critical role as a risk factor for cardiovascular mortality, encompassing conditions like coronary artery disease, organ damage, congestive heart failure, and cerebrovascular diseases. Furthermore, hypertension can lead to increased oxidation and peroxidation reactions due to elevated blood pressure and blood flow. Objective: This study aimed to evaluate the levels of superoxide dismutase in the sera of patients diagnosed with hypertension. Materials and Methods: The study involved 60 hypertensive patients who exhibited no significant abnormalities, such as liver disease, cardiomyopathy, renal disease, diabetes mellitus, congestive heart failure, or thyroid disease. Additionally, 25 healthy individuals, matched by age and sex to the patient group, were included in the study. The age range of the participants was between 32 and 70 years. The level of superoxide dismutase 1 in the sera was measured using an enzyme-linked immunosorbent assay (ELISA). Results: The results demonstrated a significant increase in the activity level of superoxide dismutase in hypertensive patients (732.91 ± 82.68 pg/ml) compared to the control group (590.63 ± 47.69 pg/ml). Conclusion: These findings have the potential to contribute to the diagnosis and management of hypertension, offering insights into the role of superoxide dismutase activity in the disease process.

Keywords

• High blood pressure, SOD1, ELISA and Systolic blood pressure