Advances of non-viral nanometer vectors delivery systemfor siRNA
Geng Xiang,
Huang Meizhou,
Li Jianyong
Affiliations
Geng Xiang
Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Key Lab of Veterinary Pharmaceutical Development,Ministry of Agriculture and Rural Aff airs, Key Lab of New Animal Drug Project of Gansu Province, Lanzhou 730050, Gansu, China
Huang Meizhou
Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Key Lab of Veterinary Pharmaceutical Development,Ministry of Agriculture and Rural Aff airs, Key Lab of New Animal Drug Project of Gansu Province, Lanzhou 730050, Gansu, China
Li Jianyong
Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Key Lab of Veterinary Pharmaceutical Development,Ministry of Agriculture and Rural Aff airs, Key Lab of New Animal Drug Project of Gansu Province, Lanzhou 730050, Gansu, China
The delivery of small interfering RNA is now mainly through viral vector delivery, chemicalmodification delivery, microinjection delivery, and non-viral nanometer vector delivery. Compared with otherdelivery methods, non-viral nanometer vector delivery has the advantages of simplicity, safety, and easyacceptance by patients. However, due to the easy hydrolytic of siRNA and the poor absorption ability of cellsto siRNA, low cell delivery efficiency, more and more study had been conducted on modification methodsto optimize siRNA and increase their application range in recent years. In this paper, we review the designof siRNA non-viral nano-vectors in recent years and provide theoretical basis for their clinical applications.
