Nature Communications (May 2021)
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness
- Lei Liu,
- Tianyu Tao,
- Shihua Liu,
- Xia Yang,
- Xuwei Chen,
- Jiaer Liang,
- Ruohui Hong,
- Wenting Wang,
- Yi Yang,
- Xiaoyi Li,
- Youhong Zhang,
- Quanfeng Li,
- Shujun Liang,
- Haocheng Yu,
- Yun Wu,
- Xinyu Guo,
- Yan Lai,
- Xiaofan Ding,
- Hongyu Guan,
- Jueheng Wu,
- Xun Zhu,
- Jie Yuan,
- Jun Li,
- Shicheng Su,
- Mengfeng Li,
- Xiuyu Cai,
- Junchao Cai,
- Han Tian
Affiliations
- Lei Liu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Tianyu Tao
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Shihua Liu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Xia Yang
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University
- Xuwei Chen
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Jiaer Liang
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Ruohui Hong
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Wenting Wang
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Yi Yang
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University
- Xiaoyi Li
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Youhong Zhang
- Cancer Institute, Southern Medical University
- Quanfeng Li
- Cancer Institute, Southern Medical University
- Shujun Liang
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Haocheng Yu
- Guangzhou No. 2 High School
- Yun Wu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Xinyu Guo
- The First School of Clinical Medicine, Southern Medical University
- Yan Lai
- State Key Laboratory of Respiratory Diseases and Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Xiaofan Ding
- Department of Surgery at the Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong
- Hongyu Guan
- Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University
- Jueheng Wu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Xun Zhu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Jie Yuan
- Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University
- Jun Li
- Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University
- Shicheng Su
- Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Mengfeng Li
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- Xiuyu Cai
- Department of General Internal Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center
- Junchao Cai
- Department of Immunology, Sun Yat-sen University Zhongshan School of Medicine
- Han Tian
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University
- DOI
- https://doi.org/10.1038/s41467-021-22971-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis.
