Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

Astrid S. Jørgensen; Viktorija Daugvilaite; Katia De Filippo; Christian Berg; Masa Mavri; Tau Benned-Jensen; Goda Juzenaite; Gertrud Hjortø; Sara Rankin; Jon Våbenø; Mette M. Rosenkilde

doi:10.1038/s42003-021-02070-9

Communications Biology (May 2021)

Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

Astrid S. Jørgensen,
Viktorija Daugvilaite,
Katia De Filippo,
Christian Berg,
Masa Mavri,
Tau Benned-Jensen,
Goda Juzenaite,
Gertrud Hjortø,
Sara Rankin,
Jon Våbenø,
Mette M. Rosenkilde

Affiliations

Astrid S. Jørgensen: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen
Viktorija Daugvilaite: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen
Katia De Filippo: Department of Medicine, National Heart and Lung Institute (NHLI), Imperial College
Christian Berg: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen
Masa Mavri: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen
Tau Benned-Jensen: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen
Goda Juzenaite: Department of Medicine, National Heart and Lung Institute (NHLI), Imperial College
Gertrud Hjortø: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen
Sara Rankin: Department of Medicine, National Heart and Lung Institute (NHLI), Imperial College
Jon Våbenø: Helgeland Hospital Trust
Mette M. Rosenkilde: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen

DOI: https://doi.org/10.1038/s42003-021-02070-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Jørgensen et al. investigate the effects of the CXCR4 targeting agents, AMD3100 (Plerixafor) and AMD11070, and show that AMD3100, unlike AMD11070, is biased with intrinsic β-arrestin recruitment agonism and full G protein antagonism. They finally propose that this biased action of AMD3100 is central for its superior therapeutic effect on mobilizing stem cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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