Role of CA125 in the Diagnosis of Acute Appendicitis

Abstract

Aim: Acute appendicitis (AA) is the most common surgical emergency in the world, and its diagnosis is mainly dependent on clinical findings. Recently, secretion of CA125 from peritoneal cells due to inflammatory stimulus has been shown. The aim of this study was to evaluate the relation between CA25 levels and AA.Materials and Methods: In this prospective trial, CA125 levels were measured. Group 1 consisted histopathologically approved AA cases. Group 2 consisted healthy individuals.Results: Seventy-four cases (37 AA and 37 healthy individuals) were included in the study. In the AA group, the mean CA125 level was 9.8±9.3 U/mL, and in the control group, it was 4.6±1.5 U/mL. In Pearson correlation analysis, the CA125 level had a positive correlation with AA (r=0.371, p=0.001).Conclusion: Recent studies demonstrate that CA125 can help distinguish patients with or without AA. CA125 levels can be used as a marker of AA in cases with clinical doubt.

Keywords

• Acute appendicitis
• diagnosis
• CA-125