Nature Communications (Oct 2021)

The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells

  • Marc Hennequart,
  • Christiaan F. Labuschagne,
  • Mylène Tajan,
  • Steven E. Pilley,
  • Eric C. Cheung,
  • Nathalie M. Legrave,
  • Paul C. Driscoll,
  • Karen H. Vousden

DOI
https://doi.org/10.1038/s41467-021-26395-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Cancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grown under these conditions the cells are less sensitive to serine withdrawal.