Extracellular Matrix Components as Diagnostic Tools in Inflammatory Bowel Disease
Laura Golusda,
Anja A. Kühl,
Britta Siegmund,
Daniela Paclik
Affiliations
Laura Golusda
Freie Universität Berlin and Humboldt Universität zu Berlin, iPATH.Berlin, Campus Benjamin Franklin, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany
Anja A. Kühl
Freie Universität Berlin and Humboldt Universität zu Berlin, iPATH.Berlin, Campus Benjamin Franklin, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany
Britta Siegmund
Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie (einschl. Arbeitsbereich Ernährungsmedizin), Campus Benjamin Franklin, Charité—Universitätsmedizin Berlin, 12203 Berlin, Germany
Daniela Paclik
Freie Universität Berlin and Humboldt Universität zu Berlin, iPATH.Berlin, Campus Benjamin Franklin, Charité—Universitätsmedizin Berlin, 12200 Berlin, Germany
Work from the last years indicates that the extracellular matrix (ECM) plays a direct role in various cellular processes, including proliferation, migration and differentiation. Besides homeostatic processes, its regulatory function in inflammation becomes more and more evident. In inflammation, such as inflammatory bowel disease, the ECM composition is constantly remodeled, and this can result in a structuring of fistulizing disease course. Thus, tracking early ECM changes might bear the potential to predict the disease course. In this review, we provide an overview of relevant diagnostic methods, focusing on ECM changes.
