Efficient S-Acylation of Thiourea

David J. Jones; Uday B. Rao Khandavilli; Eileen M. O’Leary; Simon E. Lawrence; Timothy P. O’Sullivan

doi:10.1055/s-0037-1610370

SynOpen (Oct 2018)

Efficient S-Acylation of Thiourea

David J. Jones,
Uday B. Rao Khandavilli,
Eileen M. O’Leary,
Simon E. Lawrence,
Timothy P. O’Sullivan

Affiliations

David J. Jones: School of Chemistry, University College Cork
Uday B. Rao Khandavilli: School of Chemistry, University College Cork
Eileen M. O’Leary: Department of Physical Sciences, Cork Institute of Technology
Simon E. Lawrence: School of Chemistry, University College Cork
Timothy P. O’Sullivan: School of Chemistry, University College Cork

DOI: https://doi.org/10.1055/s-0037-1610370
Journal volume & issue: Vol. 02, no. 04
pp. 0263 – 0267

Abstract

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Abstract Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.

Published in SynOpen

ISSN: 2509-9396 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Science: Chemistry
Website: https://doi.org/10.1055/s-00032269

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Abstract

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