Energy processes in isolated hepatocytes at different duration of insulin action

Abstract

Insulin effect on energy supplying processes in isolated rat hepatocytes at different duration of hormone action at succinate and α-ketoglutarate oxidation was investigated. Short-term insulin action in vitro does not influence the examined processes. In vivo insulin effect is characterized by time dependence with activation of ADP-stimulated succinate and α-ketoglutarate oxidation in isolated hepatocytes in 4 hours after injection and absence of influence in case of prolonged action (6, 12 days).

Keywords

• insulin
• hepatocytes
• succinate
• α-ketoglutarate
• adp-stimulated respiration