Nature Communications (Jun 2022)
Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation
- Yingying Shen,
- Chaojie Lu,
- Zhengbo Song,
- Chenxiao Qiao,
- Jiaoli Wang,
- Jinbiao Chen,
- Chengyan Zhang,
- Xianchang Zeng,
- Zeyu Ma,
- Tao Chen,
- Xu Li,
- Aifu Lin,
- Jufeng Guo,
- Jianli Wang,
- Zhijian Cai
Affiliations
- Yingying Shen
- Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Chaojie Lu
- Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Zhengbo Song
- Department of Medical Oncology, Zhejiang Cancer Hospital
- Chenxiao Qiao
- Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Jiaoli Wang
- Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine
- Jinbiao Chen
- Department of Oncology, Hangzhou Xixi Hospital
- Chengyan Zhang
- Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Xianchang Zeng
- Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Zeyu Ma
- Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Tao Chen
- Department of Orthopedics, Musculoskeletal Tumor Center, the Second Affiliated Hospital, Zhejiang University School of Medicine
- Xu Li
- School of Life Science, Westlake University
- Aifu Lin
- College of Life Sciences, Zhejiang University
- Jufeng Guo
- Department of Breast Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine
- Jianli Wang
- Institute of Immunology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Zhijian Cai
- Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31141-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
TGF-β can function to increase Treg cell function and reduce anti-tumour immunity. Here the authors show that UDCA is a potential mediator that can reduce TGF-β activity and promote anti-tumour immune responses in mice and can be additive to other checkpoint inhibitors.
