PLoS ONE (Jan 2023)

Weight loss during follow-up in patients with acute heart failure: From the KCHF registry.

  • Yuta Seko,
  • Takao Kato,
  • Takeshi Morimoto,
  • Hidenori Yaku,
  • Yasutaka Inuzuka,
  • Yodo Tamaki,
  • Neiko Ozasa,
  • Masayuki Shiba,
  • Erika Yamamoto,
  • Yusuke Yoshikawa,
  • Takeshi Kitai,
  • Yugo Yamashita,
  • Moritake Iguchi,
  • Kazuya Nagao,
  • Yuichi Kawase,
  • Takashi Morinaga,
  • Mamoru Toyofuku,
  • Yutaka Furukawa,
  • Kenji Ando,
  • Kazushige Kadota,
  • Yukihito Sato,
  • Koichiro Kuwahara,
  • Takeshi Kimura

DOI
https://doi.org/10.1371/journal.pone.0287637
Journal volume & issue
Vol. 18, no. 6
p. e0287637

Abstract

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BackgroundsThe prognostic implication of weight loss after discharge from acute heart failure (AHF) remains unclear. We sought to investigate the association of weight loss between discharge and 6-month visit with subsequent clinical outcomes in patients with AHF.MethodsWe analyzed 686 patients with AHF in the prospective longitudinal follow-up study derived from the Kyoto Congestive Heart Failure registry, and divided them into 2 groups based on the weight loss at 6-month index visit. We defined the weight loss as ≥ 5% decrease in body weight from discharge to 6-month index visit.ResultsThere were 90 patients (13.1%) with a weight loss at 6-month visit. Patients in the weight loss group compared with those in the no weight loss group had higher body weight at discharge and lower body weight at 6-mont visit. Patients in the weight loss group had a lower systolic blood pressure, higher brain-type natriuretic peptide, lower serum albumin, lower hemoglobin, higher prevalence of heart failure with reduced ejection fraction at 6-month visit, and a lower prescription rate of inhibitors of renin-angiotensin system than those in the no weight loss group. The cumulative 6-month incidence of all-cause death was significantly higher in the weight loss group than in the no weight loss group (14.2% and 4.3%, log-rank PConclusionBody weight loss of ≥5% at 6-month visit after discharge was associated with subsequent all-cause death in patients with AHF.