Two new Mn(II) coordination polymers: Photocatalytic property and treatment activity on colorectal cancer by inhibiting cancer cell migration and invasion

Abstract

Two new binary Mn(II) coordination polymers, namely [Mn(5-MeO-ip)(DMF)]n (1) and [Mn(obb)]n (2) (5-MeO-H2ip = 5-methoxyisophthalic acid, H2obb = 4,4′-oxydibenzoic acid), have been synthesized via the self-assemble reactions of Mn(II) ions with two different dicarboxylic acid ligands. The optical band gaps for 1–2 are 3.21 eV, 3.50 eV, respectively, and their photocatalytic properties for the degradation of MV under UV light irradiation were also investigated. For the colorectal cancer treatment, the biological activity was evaluated and the specific mechanism was explored at the same time. Firstly, the inhibitory activity of the new compounds on the colorectal cancer cell viability was measured with CCK-8 assay. Next, the real time RT-PCR was used to measure the activation of the VEGF signaling pathway in the colorectal cancer cells after compound treatment.

Keywords

• Mn(II) compound
• Photocatalysis
• Colorectal cancer