Cancer Medicine (Aug 2023)

Induction chemotherapy‐based organ‐preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer—Results of a matched‐pair analysis

  • Yifan Yang,
  • Ling Feng,
  • Qi Zhong,
  • Yang Zhang,
  • Zhigang Huang,
  • Shurong Zhang,
  • Shuling Li,
  • Junmao Gao,
  • Lizhen Hou,
  • Hongzhi Ma,
  • Shizhi He,
  • Qian Shi,
  • Meng Lian,
  • Yanming Zhao,
  • Xixi Shen,
  • Jiaming Chen,
  • Lingwa Wang,
  • Haiyang Li,
  • Shaoshi Chen,
  • Jiaqi Xu,
  • Ru Wang,
  • Jugao Fang

DOI
https://doi.org/10.1002/cam4.6354
Journal volume & issue
Vol. 12, no. 16
pp. 17078 – 17086

Abstract

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Abstract Background We performed a paired analysis to compare the therapeutic effect between the induction chemotherapy‐based organ‐preservation approach and immediate total laryngectomy in hypopharyngeal squamous cell carcinoma patients requiring total laryngectomy. Methods 351 patients who were treated with organ‐preservation approach were compared with 110 patients who were treated with total laryngectomy. The main measures and outcomes were progression‐free survival (PFS), overall survival (OS), and larynx function preservation survival (LFPS). Results No statistical difference was observed for 3‐, 5‐, and 10‐year PFS and OS in two groups. In the organ‐preservation group, the 3‐, 5‐, and 10‐year LFPS was 30.7%, 23.3%, and 16.6%, respectively. The LFPS of Stage III > Stage IV, N0 > N1 > N2 > N3, T2 > T3 > T4, CR > PR > SD > PD patients (all p values <0.05). Conclusions Survival outcomes did not significantly differ between the two groups. The organ‐preservation approach allowed more than 70% of the survivors to retain their larynx function.

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