Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes

Abstract

Abstract Objective To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes. Methods We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound. Results The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P P Conclusions Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.

Keywords

• Osteocalcin
• Intima-media thickness
• Carotid atherosclerotic plaques
• Atherosclerosis