Nature Communications (May 2021)
Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer
- Fengying Wu,
- Jue Fan,
- Yayi He,
- Anwen Xiong,
- Jia Yu,
- Yixin Li,
- Yan Zhang,
- Wencheng Zhao,
- Fei Zhou,
- Wei Li,
- Jie Zhang,
- Xiaosheng Zhang,
- Meng Qiao,
- Guanghui Gao,
- Shanhao Chen,
- Xiaoxia Chen,
- Xuefei Li,
- Likun Hou,
- Chunyan Wu,
- Chunxia Su,
- Shengxiang Ren,
- Margarete Odenthal,
- Reinhard Buettner,
- Nan Fang,
- Caicun Zhou
Affiliations
- Fengying Wu
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Jue Fan
- Singleron Biotechnologies
- Yayi He
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Anwen Xiong
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Jia Yu
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Yixin Li
- Singleron Biotechnologies
- Yan Zhang
- Singleron Biotechnologies
- Wencheng Zhao
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Fei Zhou
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Wei Li
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Jie Zhang
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Xiaosheng Zhang
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Meng Qiao
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Guanghui Gao
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Shanhao Chen
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Xiaoxia Chen
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Xuefei Li
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Likun Hou
- Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Chunyan Wu
- Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Chunxia Su
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Shengxiang Ren
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Margarete Odenthal
- Institute of Pathology, University Hospital of Cologne
- Reinhard Buettner
- Institute of Pathology, University Hospital of Cologne
- Nan Fang
- Singleron Biotechnologies
- Caicun Zhou
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-22801-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Comprehensive profiles of tumour and microenvironment are critical to understand heterogeneity in non-small cell lung cancer (NSCLC). Here, the authors profile 42 late-stage NSCLC patients with single-cell RNA-seq, revealing immune landscapes that are associated with cancer subtype or heterogeneity.
