Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC
Salvi Rosario,
Meoli Ilernando,
Cennamo Antonio,
Perrotta Fabio,
Saverio Cerqua Francesco,
Montesano Raffaele,
Curcio Carlo,
Lassandro Francesco,
Stefanelli Francesco,
Grella Edoardo,
Tafuri Domenico,
Mazzarella Gennaro,
Bianco Andrea
Affiliations
Salvi Rosario
Unit of Thoracic Surgery, A.O. Dei Colli - Monaldi Hospital, Naples, Italy
Meoli Ilernando
Unit of Pneumology, A.O. Dei Colli - Monaldi Hospital, Naples, Italy
Cennamo Antonio
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, A.O. Dei Colli - Monaldi Hospital, Via Leonardo Bianchi, 80131, Naples, Italy
Perrotta Fabio
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, A.O. Dei Colli - Monaldi Hospital, Via Leonardo Bianchi, 80131, Naples, Italy
Saverio Cerqua Francesco
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, A.O. Dei Colli - Monaldi Hospital, Via Leonardo Bianchi, 80131, Naples, Italy
Montesano Raffaele
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, A.O. Dei Colli - Monaldi Hospital, Via Leonardo Bianchi, 80131, Naples, Italy
Curcio Carlo
Unit of Thoracic Surgery, A.O. Dei Colli - Monaldi Hospital, Naples, Italy
Lassandro Francesco
Unit of Radiology, A.O. Dei Colli - Monaldi Hospital, Naples, Italy
Stefanelli Francesco
Unit of Pneumology, A.O. Dei Colli - Monaldi Hospital, Naples, Italy
Grella Edoardo
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, A.O. Dei Colli - Monaldi Hospital, Via Leonardo Bianchi, 80131, Naples, Italy
Tafuri Domenico
Department of Sport Sciences and Wellness, University of Naples “Parthenope”, Naples, Italy
Mazzarella Gennaro
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, A.O. Dei Colli - Monaldi Hospital, Via Leonardo Bianchi, 80131, Naples, Italy
Bianco Andrea
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples/Hosp. Monaldi, Piazza Miraglia, 2, 80138 Naples, Italy Phone:+390815665228, Fax: +390815665230, E-mail: [email protected]
Thoracic surgery remains the better therapeutic option for non-small cell lung cancer patients that are diagnosed in early stage disease. Preoperative lung function assessment includes respiratory function tests (RFT) and cardio-pulmonary exercise testing (CPET). Vo2 peak, FEV1 and DLCO as well as recognition of performance status, presence of co-morbidities, frailty indexes, and age predict the potential impact of surgical resection on patient health status and survival risk. In this study we have retrospectively assessed the benefit of a high-intensity preoperative pulmonary rehabilitation program (PRP) in 14 patients with underlying lung function impairment prior to surgery. Amongst these, three patients candidate to surgical resection exhibited severe functional impairment associated with high score of frailty according CHS and SOF index, resulting in a substantial mortality risk.
