BMJ Open (Aug 2023)
WHO O2CoV2: oxygen requirements and respiratory support in patients with COVID-19 in low-and-middle income countries—protocol for a multicountry, prospective, observational cohort study
- ,
- Jie Li,
- Rashan Haniffa,
- Yaseen M Arabi,
- Srinivas Murthy,
- Sylvie Chevret,
- Ludovic Reveiz,
- Christophe Guitton,
- Janet Diaz,
- Devasahayam J Christopher,
- John C Marshall,
- Neill Adhikari,
- Rob Fowler,
- Leticia Kawano-Dourado,
- Arthur Kwizera,
- Tim Baker,
- Djillali Annane,
- Pauline Convocar,
- Elisabeth Riviello,
- Madiha Hashmi,
- Jonathan AC Sterne,
- Jorge Salluh,
- Diptesh Aryal,
- Pryanka Relan,
- Richard Kojan,
- Wangari Waweru-Siika,
- Chiori Kodama,
- Neale Batra,
- Sara Dominguez Rodriguez,
- Martha Gartley,
- Ewan Goligher,
- Devachandran Jayakumar,
- Richard H Kallet,
- Armand Mekontso-Dessap,
- Christian Paletta,
- Ingrid Lara Rendon,
- Bruno Martins Tomazini,
- Bharath Kumar Tirupakuzhi Vijayaraghavan,
- Fernando Zampieri,
- Gasim Amrahli,
- John Appiah,
- Kieran Bligh,
- Mohammed Derow,
- Laura Alejandra Velez Ruiz Gaitan,
- Itziar Carrasco Garcia,
- Bridget Griffith,
- Rashidatu Kamara,
- Gary Kuniyoshi,
- Maria Mendes,
- Dina Pfeifer,
- Cinzia DeBrito Procopio,
- Matthieu Rolland,
- Amadou Seck,
- Elizabeth Stanway,
- Julie Viry,
- Pushpa Wijesinghe
Affiliations
- recovering patient, Eden Unit
- Jie Li
- 13Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China
- Rashan Haniffa
- Yaseen M Arabi
- Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
- Srinivas Murthy
- Department of Pediatrics, Division of Critical Care, The University of British Columbia, Vancouver, British Columbia, Canada
- Sylvie Chevret
- 23 Department of Biostatistics and Medical Informatics, University of Paris, Paris, France
- Ludovic Reveiz
- Pan American Health Organization, Washington, District of Columbia, USA
- Christophe Guitton
- Médecine intensive réanimation, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France
- Janet Diaz
- COVID-19 Clinical Management, World Health Emergencies Programme, World Health Organization, Geneva, Switzerland
- Devasahayam J Christopher
- Department of Pulmonary Medicine, Christian Medical College and Hospital (CMC), Vellore, India
- John C Marshall
- Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
- Neill Adhikari
- Rob Fowler
- H Barrie Fairley professor of critical care medicine
- Leticia Kawano-Dourado
- respiratory medicine physician
- Arthur Kwizera
- critical care physician
- Tim Baker
- Health Systems, Impact Evaluation and Policy, Ifakara Health Institute, Ifakara, Tanzania
- Djillali Annane
- 2 General Intensive Care Unit, Hopital Raymond-Poincare, Garches, France
- Pauline Convocar
- Corazon Locsin Montelibano Memorial Medical Hospital, Manila Doctors Hospital, Southern Philippines Medical Center, Manila, Philippines
- Elisabeth Riviello
- Madiha Hashmi
- Department of Critical Care Medicine, Ziauddin University, Karachi, Pakistan
- Jonathan AC Sterne
- Population Health Sciences, University of Bristol, Bristol, UK
- Jorge Salluh
- D`Or Institute for Research and Education, Rio de Janeiro, Brazil
- Diptesh Aryal
- intensivist
- Pryanka Relan
- COVID-19 Clinical Management, World Health Emergencies Programme, World Health Organization, Geneva, Switzerland
- Richard Kojan
- Wangari Waweru-Siika
- Aga Khan University (AKU), Nairobi, Kenya
- Chiori Kodama
- WHO Health Emergencies Programme, WHO Regional Office for the Eastern Mediterranean, Cairo, Egypt
- Neale Batra
- 1 WHO Health Emergencies Programme, WHO Headquarters, Geneva, Switzerland
- Sara Dominguez Rodriguez
- World Health Organization, Geneva, Switzerland
- Martha Gartley
- Ewan Goligher
- Devachandran Jayakumar
- Richard H Kallet
- Armand Mekontso-Dessap
- Christian Paletta
- Ingrid Lara Rendon
- Bruno Martins Tomazini
- Bharath Kumar Tirupakuzhi Vijayaraghavan
- Fernando Zampieri
- Gasim Amrahli
- John Appiah
- Kieran Bligh
- Mohammed Derow
- Laura Alejandra Velez Ruiz Gaitan
- Itziar Carrasco Garcia
- Bridget Griffith
- Rashidatu Kamara
- Gary Kuniyoshi
- Maria Mendes
- Dina Pfeifer
- Cinzia DeBrito Procopio
- Matthieu Rolland
- Amadou Seck
- Elizabeth Stanway
- Julie Viry
- Pushpa Wijesinghe
- DOI
- https://doi.org/10.1136/bmjopen-2022-071346
- Journal volume & issue
-
Vol. 13,
no. 8
Abstract
Introduction SARS-CoV-2 has been identified as the cause of the disease officially named COVID-19, primarily a respiratory illness. COVID-19 was characterised as a pandemic on 11 March 2020. It has been estimated that approximately 20% of people with COVID-19 require oxygen therapy. Oxygen has been listed on the WHO Model List of Essential Medicines List and Essential Medicines List for Children for almost two decades. The COVID-19 pandemic has highlighted, more than ever, the acute need for scale-up of oxygen therapy. Detailed data on the use of oxygen therapy in low-and-middle income countries at the patient and facility level are needed to target interventions better globally.Methods and analysis We aim to describe the requirements and use of oxygen at the facility and patient level of approximately 4500 patients with COVID-19 in 30 countries. Our objectives are specifically to characterise type and duration of different modalities of oxygen therapy delivered to patients; describe demographics and outcomes of hospitalised patients with COVID-19; and describe facility-level oxygen production and support. Primary analyses will be descriptive in nature. Respiratory support transitions will be described in Sankey plots, and Kaplan-Meier models will be used to estimate probability of each transition. A multistate model will be used to study the course of hospital stay of the study population, evaluating transitions of escalating respiratory support transitions to the absorbing states.Ethics and dissemination WHO Ad Hoc COVID-19 Research Ethics Review Committee (ERC) has approved this global protocol. When this protocol is adopted at specific country sites, national ERCs may make require adjustments in accordance with their respective national research ethics guidelines. Dissemination of this protocol and global findings will be open access through peer-reviewed scientific journals, study website, press and online media.Trial registration number NCT04918875.
