Reactions of 3-amino-1,2,4-triazine with coupling reagents and electrophiles

Abstract

Analogs of a new heterocyclic system were obtained from the reactions of 3-amino-1,2,4-triazine with coupling reagents such as boronic acids, and terminal alkynes in the presence of a palladium catalyst. Other reactions such as amination of the triazine at position 5, followed by electrophilic reactions with phenyl isocyanates and benzoyl chlorides, were performed to form new monoureido and benzoylated compounds.

Keywords

• 3-amino-1,2,4-triazine
• heterocyclic
• electrophilic
• monoureido
• benzoylated