Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33

Fei Zhang; Liman Zhou; Fandong Kong; Qingyun Ma; Qingyi Xie; Jiuhui Li; Haofu Dai; Lei Guo; Youxing Zhao

doi:10.3390/md18010067

Marine Drugs (Jan 2020)

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus <i>Cladosporium</i> sp. KFD33

Fei Zhang,
Liman Zhou,
Fandong Kong,
Qingyun Ma,
Qingyi Xie,
Jiuhui Li,
Haofu Dai,
Lei Guo,
Youxing Zhao

Affiliations

Fei Zhang: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Liman Zhou: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Fandong Kong: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Qingyun Ma: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Qingyi Xie: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Jiuhui Li: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Haofu Dai: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Lei Guo: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, China
Youxing Zhao: Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China

DOI: https://doi.org/10.3390/md18010067
Journal volume & issue: Vol. 18, no. 1
p. 67

Abstract

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Five new perylenequinone derivatives, altertoxins VIII−XII (1−5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1−6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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