Nature Communications (Nov 2022)
Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk
- Xuehai Wang,
- Michael Nissen,
- Deanne Gracias,
- Manabu Kusakabe,
- Guillermo Simkin,
- Aixiang Jiang,
- Gerben Duns,
- Clementine Sarkozy,
- Laura Hilton,
- Elizabeth A. Chavez,
- Gabriela C. Segat,
- Rachel Wong,
- Jubin Kim,
- Tomohiro Aoki,
- Rashedul Islam,
- Christina May,
- Stacy Hung,
- Kate Tyshchenko,
- Ryan R. Brinkman,
- Martin Hirst,
- Aly Karsan,
- Ciara Freeman,
- Laurie H. Sehn,
- Ryan D. Morin,
- Andrew J. Roth,
- Kerry J. Savage,
- Jeffrey W. Craig,
- Sohrab P. Shah,
- Christian Steidl,
- David W. Scott,
- Andrew P. Weng
Affiliations
- Xuehai Wang
- Terry Fox Laboratory, BC Cancer Agency
- Michael Nissen
- Terry Fox Laboratory, BC Cancer Agency
- Deanne Gracias
- Terry Fox Laboratory, BC Cancer Agency
- Manabu Kusakabe
- Terry Fox Laboratory, BC Cancer Agency
- Guillermo Simkin
- Terry Fox Laboratory, BC Cancer Agency
- Aixiang Jiang
- Lymphoid Cancer Research, BC Cancer Agency
- Gerben Duns
- Lymphoid Cancer Research, BC Cancer Agency
- Clementine Sarkozy
- Lymphoid Cancer Research, BC Cancer Agency
- Laura Hilton
- Lymphoid Cancer Research, BC Cancer Agency
- Elizabeth A. Chavez
- Lymphoid Cancer Research, BC Cancer Agency
- Gabriela C. Segat
- Terry Fox Laboratory, BC Cancer Agency
- Rachel Wong
- Terry Fox Laboratory, BC Cancer Agency
- Jubin Kim
- Terry Fox Laboratory, BC Cancer Agency
- Tomohiro Aoki
- Lymphoid Cancer Research, BC Cancer Agency
- Rashedul Islam
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Christina May
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Stacy Hung
- Lymphoid Cancer Research, BC Cancer Agency
- Kate Tyshchenko
- Terry Fox Laboratory, BC Cancer Agency
- Ryan R. Brinkman
- Terry Fox Laboratory, BC Cancer Agency
- Martin Hirst
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Aly Karsan
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Ciara Freeman
- Lymphoid Cancer Research, BC Cancer Agency
- Laurie H. Sehn
- Lymphoid Cancer Research, BC Cancer Agency
- Ryan D. Morin
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Andrew J. Roth
- Molecular Oncology, BC Cancer Agency
- Kerry J. Savage
- Lymphoid Cancer Research, BC Cancer Agency
- Jeffrey W. Craig
- Lymphoid Cancer Research, BC Cancer Agency
- Sohrab P. Shah
- Molecular Oncology, BC Cancer Agency
- Christian Steidl
- Lymphoid Cancer Research, BC Cancer Agency
- David W. Scott
- Lymphoid Cancer Research, BC Cancer Agency
- Andrew P. Weng
- Terry Fox Laboratory, BC Cancer Agency
- DOI
- https://doi.org/10.1038/s41467-022-34408-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Follicular lymphoma can transform to a more aggressive histology. Here, the authors use bulk and single cell analysis to create a 26 marker panel which could be used to profile FL samples and predict the risk of transformation using flow cytometry.
