Nature Communications (Oct 2020)
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19
- Guillaume Carissimo,
- Weili Xu,
- Immanuel Kwok,
- Mohammad Yazid Abdad,
- Yi-Hao Chan,
- Siew-Wai Fong,
- Kia Joo Puan,
- Cheryl Yi-Pin Lee,
- Nicholas Kim-Wah Yeo,
- Siti Naqiah Amrun,
- Rhonda Sin-Ling Chee,
- Wilson How,
- Stephrene Chan,
- Bingwen Eugene Fan,
- Anand Kumar Andiappan,
- Bernett Lee,
- Olaf Rötzschke,
- Barnaby Edward Young,
- Yee-Sin Leo,
- David Chien Lye,
- Laurent Renia,
- Lai Guan Ng,
- Anis Larbi,
- Lisa FP Ng
Affiliations
- Guillaume Carissimo
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Weili Xu
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Immanuel Kwok
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Mohammad Yazid Abdad
- National Centre for Infectious Diseases
- Yi-Hao Chan
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Siew-Wai Fong
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Kia Joo Puan
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Cheryl Yi-Pin Lee
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Nicholas Kim-Wah Yeo
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Siti Naqiah Amrun
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Rhonda Sin-Ling Chee
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Wilson How
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Stephrene Chan
- Department of Haematology, Tan Tock Seng Hospital
- Bingwen Eugene Fan
- Department of Haematology, Tan Tock Seng Hospital
- Anand Kumar Andiappan
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Bernett Lee
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Olaf Rötzschke
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Barnaby Edward Young
- National Centre for Infectious Diseases
- Yee-Sin Leo
- National Centre for Infectious Diseases
- David Chien Lye
- National Centre for Infectious Diseases
- Laurent Renia
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- Lai Guan Ng
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Anis Larbi
- Singapore Immunology Network, Agency for Science, Technology and Research, Immunos
- Lisa FP Ng
- Infectious Disease Horizontal Technology Center, Agency for Science, Technology and Research, Immunos
- DOI
- https://doi.org/10.1038/s41467-020-19080-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.
