Disseminated sarcoidosis involving lymph nodes, bone and spleen with progressive cardiac sarcoidosis on 18F-FDG PET/CT and cardiac MRI

James Yuheng Jiang, MD, MMed (ClinEpi); Veronica Chi Ken Wong, MBBS, FRACP; James Yun, MBBS PhD FRACP FRCPA; Faraz Pathan, MBBS PhD FRACP; Robert Mansberg, MBBS, FRACP, FAANMS

Radiology Case Reports (Nov 2021)

Disseminated sarcoidosis involving lymph nodes, bone and spleen with progressive cardiac sarcoidosis on 18F-FDG PET/CT and cardiac MRI

James Yuheng Jiang, MD, MMed (ClinEpi),
Veronica Chi Ken Wong, MBBS, FRACP,
James Yun, MBBS PhD FRACP FRCPA,
Faraz Pathan, MBBS PhD FRACP,
Robert Mansberg, MBBS, FRACP, FAANMS

Affiliations

James Yuheng Jiang, MD, MMed (ClinEpi): Department of Nuclear Medicine and PET, Nepean Hospital, Kingswood, New South Wales, 2747, Australia; Corresponding author. J.Y. Jiang
Veronica Chi Ken Wong, MBBS, FRACP: Department of Nuclear Medicine and PET, Nepean Hospital, Kingswood, New South Wales, 2747, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 2006, Australia
James Yun, MBBS PhD FRACP FRCPA: Department of Clinical Immunology and Allergy, Nepean Hospital, Kingswood, New South Wales, 2747, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 2006, Australia
Faraz Pathan, MBBS PhD FRACP: Department of Cardiology, Nepean Hospital, Kingswood, New South Wales, 2747, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 2006, Australia
Robert Mansberg, MBBS, FRACP, FAANMS: Department of Nuclear Medicine and PET, Nepean Hospital, Kingswood, New South Wales, 2747, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 2006, Australia

Journal volume & issue: Vol. 16, no. 11
pp. 3610 – 3613

Abstract

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A 63-year-old lady with a background of ischemic heart disease was referred for 18F-FDG PET/CT for multiple lytic bone lesions which showed disseminated FDG avid lesions in the skeleton, nodal stations as well as spleen simulating advanced malignancy such as diffuse lymphomatous disease. A diagnosis of sarcoidosis was pathologically confirmed with bone biopsy. Following treatment, repeat PET/CT revealed significant regression of FDG avid lesions, however prominent uptake in the lateral ventricular wall was suspicious for active cardiac sarcoidosis, particularly given recurrent chest pain. This was confirmed on cardiac MRI and correlation with PET enabled discrimination between ischemic and non-ischemic fibrosis.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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