Nature Communications (Jun 2019)
Orchestrated ensemble activities constitute a hippocampal memory engram
- Khaled Ghandour,
- Noriaki Ohkawa,
- Chi Chung Alan Fung,
- Hirotaka Asai,
- Yoshito Saitoh,
- Takashi Takekawa,
- Reiko Okubo-Suzuki,
- Shingo Soya,
- Hirofumi Nishizono,
- Mina Matsuo,
- Makoto Osanai,
- Masaaki Sato,
- Masamichi Ohkura,
- Junichi Nakai,
- Yasunori Hayashi,
- Takeshi Sakurai,
- Takashi Kitamura,
- Tomoki Fukai,
- Kaoru Inokuchi
Affiliations
- Khaled Ghandour
- Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
- Noriaki Ohkawa
- Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
- Chi Chung Alan Fung
- CREST, Japan Science and Technology Agency (JST)
- Hirotaka Asai
- Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
- Yoshito Saitoh
- Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
- Takashi Takekawa
- CREST, Japan Science and Technology Agency (JST)
- Reiko Okubo-Suzuki
- Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
- Shingo Soya
- WPI-IIIS, University of Tsukuba
- Hirofumi Nishizono
- CREST, Japan Science and Technology Agency (JST)
- Mina Matsuo
- Life Sciences Research Center, University of Toyama
- Makoto Osanai
- Tohoku University Graduate School of Medicine
- Masaaki Sato
- RIKEN Center for Brain Science
- Masamichi Ohkura
- Graduate School of Sciences and Engineering, Saitama University
- Junichi Nakai
- Graduate School of Sciences and Engineering, Saitama University
- Yasunori Hayashi
- RIKEN Center for Brain Science
- Takeshi Sakurai
- WPI-IIIS, University of Tsukuba
- Takashi Kitamura
- Department of Psychiatry, University of Texas Southwestern Medical Center
- Tomoki Fukai
- CREST, Japan Science and Technology Agency (JST)
- Kaoru Inokuchi
- Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
- DOI
- https://doi.org/10.1038/s41467-019-10683-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to constitute an entire memory.
