Data on nephroprotective effect of all-trans retinoic acid in early diabetic nephropathy
Edith Sierra-Mondragón,
Eduardo Molina-Jijón,
Carmen Namorado-Tónix,
Rafael Rodríguez-Muñoz,
José Pedraza-Chaverri,
José L. Reyes
Affiliations
Edith Sierra-Mondragón
Departamento de Fisiología, Biofísica, y Neurociencias, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México CDMX 07360, Mexico
Eduardo Molina-Jijón
Glomerular Disease Therapeutic Laboratory, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States
Carmen Namorado-Tónix
Departamento de Fisiología, Biofísica, y Neurociencias, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México CDMX 07360, Mexico
Rafael Rodríguez-Muñoz
Departamento de Fisiología, Biofísica, y Neurociencias, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México CDMX 07360, Mexico
José Pedraza-Chaverri
Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México (UNAM), México CDMX 04510, Mexico
José L. Reyes
Departamento de Fisiología, Biofísica, y Neurociencias, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México CDMX 07360, Mexico; Corresponding author. Fax: +55 5747 3754.
Data showed in this report are related to the research article entitled “All-trans retinoic acid ameliorates inflammatory response mediated by TLR4/NF-кB during the initiation of diabetic nephropathy” by Sierra-Mondragon et al. (2018) [1]. Diabetic nephropathy (DN) has become the main cause of renal failure. Inflammatory molecules such as cytokines, chemokines and growth factors play a key role in DN-induced renal injury Pichler et al. (2016) [2]. Results illustrate the effect of all-trans retinoic acid (ATRA), an active metabolite of vitamin A, on the renal alterations related to diabetes, among them glomerular and tubular dysfunction, and its effect on renal inflammation in different nephron segments: glomeruli, proximal and distal tubules in an initial stage of DN. Data were obtained by physical-biochemical measurements and Western blot assays performed on isolated glomeruli, proximal and distal tubules from rat kidneys. Keywords: Diabetic nephropathy, Inflammation, All-trans retinoic acid, Cytokines
