Педиатрическая фармакология (Feb 2017)

LACTOFERIN IN THE PROBLEM OF ANTI-INFECTIOUS PROTECTION OF BABIES IN THEIR FIRST YEAR OF LIVING

  • P. E. Sadchikov,
  • I. G. Goldman,
  • L. S. Namazova-Baranova,
  • G. V. Yatsik,
  • T. E. Borovik,
  • A. D. Chernousov,
  • А. I. Romanchenko,
  • E. R. Sadchikova,
  • O. L. Lukoyanova,
  • N. G. Zvonkova,
  • I. A. Belyaeva

DOI
https://doi.org/10.15690/pf.v13i6.1677
Journal volume & issue
Vol. 13, no. 6
pp. 607 – 613

Abstract

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The author summarizes the results of research of the antibacterial, antiviral and antifungal properties of multifunctional human protein — lactoferrin, in order to determine the prospects for its use in the prevention and treatment of infectious diseases of children in their first year of life. The mechanisms of anti-infectious effect of this protein with breastfed children have been described. Basic differences between human lactoferrin and cattle lactoferrin have been shown. Biotechnology of obtaining recombinant human lactoferrin from the milk of genetically engineered dairy animals (goat-producers) has been described. According to the studies, both by physical and chemical parameters and biological activity, human lactoferrin, obtained from milk-producing goats, corresponds to its natural counterpart.

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