Prognostic Significant of Neutrophil: Lymphocyte Ratio, Platelet – Lymphocyte ratio, and Lymphocyte – Monocyte ratio in Kurdish Patients with breast cancer

Abstract

Objective: The purpose of this study was to investigate the prognostic impact of neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) on breast cancer given overall survival. Patients and Methods: We retrospectively evaluated patients diagnosed with primary breast cancer from 2004 to 2020. The association between NLR, dNLR, LMR, and PLR and overall survival (OS) was analyzed. Results: The one-year, three-year, five-year, and ten-year OS were 96%, 83%, 78%, 71%, and 63%, respectively. The parameters associated with patients with breast cancer included lymph node involvement, distant metastasis, and staging. We evaluated the baseline characteristics of the patients, according to the PLR, NLR, dNLR, and LMR, and found no significant differences. Conclusions: Serum inflammatory indicators such as neutrophil, lymphocyte, as well as NLR dNLR, LMR, and PLR, were shown to have no significant influence on prognosis in patients with breast cancer. Prospective research with a larger population of patients will provide more reliable results.

Keywords

• breast cancer
• prognosis
• neutrophil-to-lymphocyte ratio
• platelet to lymphocyte ratio
• lymphocyte-to-monocyte ratio