Communications Biology (May 2022)
Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction
- Saba Nayar,
- Elena Pontarini,
- Joana Campos,
- Onorina Berardicurti,
- Charlotte G. Smith,
- Saba Asam,
- David H. Gardner,
- Serena Colafrancesco,
- Davide Lucchesi,
- Rachel Coleby,
- Ming-May Chung,
- Valentina Iannizzotto,
- Kelly Hunter,
- Simon J. Bowman,
- Gianluca Carlesso,
- Ronald Herbst,
- Helen M. McGettrick,
- Jeff Browning,
- Christopher D. Buckley,
- Benjamin A. Fisher,
- Michele Bombardieri,
- Francesca Barone
Affiliations
- Saba Nayar
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Elena Pontarini
- Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London
- Joana Campos
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Onorina Berardicurti
- Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, University of L’Aquila
- Charlotte G. Smith
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Saba Asam
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- David H. Gardner
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Serena Colafrancesco
- Rheumatology Unit, University of Rome
- Davide Lucchesi
- Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London
- Rachel Coleby
- Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London
- Ming-May Chung
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Valentina Iannizzotto
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Kelly Hunter
- Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham
- Simon J. Bowman
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Gianluca Carlesso
- Early Oncology ICA, AstraZeneca, One Medimmune Way
- Ronald Herbst
- Early Oncology ICA, AstraZeneca, One Medimmune Way
- Helen M. McGettrick
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Jeff Browning
- Departments of Microbiology and Rheumatology, Boston University School of Medicine
- Christopher D. Buckley
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Benjamin A. Fisher
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- Michele Bombardieri
- Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London
- Francesca Barone
- Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital
- DOI
- https://doi.org/10.1038/s42003-022-03344-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
The study suggests a link between ICOS-ICOSL signaling and LTa3 induction on T cells. LTa3 subsequently activates fibroblasts in the salivary gland, leading to formation of tertiary lymphoid tissues (TLS).
