Mediators of Inflammation (Jan 2022)

Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies

  • Afifah Zahirah Abd Rami,
  • Adila A. Hamid,
  • Nur Najmi Mohamad Anuar,
  • Amilia Aminuddin,
  • Azizah Ugusman

DOI
https://doi.org/10.1155/2022/2734321
Journal volume & issue
Vol. 2022

Abstract

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Initially thought to only provide mechanical support for the underlying blood vessels, perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A healthy PVAT exerts anticontractile and anti-inflammatory actions on the underlying vasculature via the release of adipocytokines such as adiponectin, nitric oxide, and omentin. However, dysfunctional PVAT produces more proinflammatory adipocytokines such as leptin, resistin, interleukin- (IL-) 6, IL-1β, and tumor necrosis factor-alpha, thus inducing an inflammatory response that contributes to the pathogenesis of vascular diseases. In this review, current knowledge on the role of PVAT inflammation in the development of vascular pathologies such as atherosclerosis and hypertension was discussed.