Voltage-sensing phosphatase (Vsp) regulates endocytosis-dependent nutrient absorption in chordate enterocytes

Adisorn Ratanayotha; Makoto Matsuda; Yukiko Kimura; Fumiko Takenaga; Tomoaki Mizuno; Md. Israil Hossain; Shin-ichi Higashijima; Takafumi Kawai; Michio Ogasawara; Yasushi Okamura

doi:10.1038/s42003-022-03916-6

Communications Biology (Sep 2022)

Voltage-sensing phosphatase (Vsp) regulates endocytosis-dependent nutrient absorption in chordate enterocytes

Adisorn Ratanayotha,
Makoto Matsuda,
Yukiko Kimura,
Fumiko Takenaga,
Tomoaki Mizuno,
Md. Israil Hossain,
Shin-ichi Higashijima,
Takafumi Kawai,
Michio Ogasawara,
Yasushi Okamura

Affiliations

Adisorn Ratanayotha: Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University
Makoto Matsuda: Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University
Yukiko Kimura: Exploratory Research Center on Life and Living Systems and National Institute for Basic Biology, National Institutes of Natural Sciences
Fumiko Takenaga: Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University
Tomoaki Mizuno: Center for Medical Research and Education, Osaka University
Md. Israil Hossain: Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University
Shin-ichi Higashijima: Exploratory Research Center on Life and Living Systems and National Institute for Basic Biology, National Institutes of Natural Sciences
Takafumi Kawai: Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University
Michio Ogasawara: Department of Biology, Graduate School of Science, Chiba University
Yasushi Okamura: Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University

DOI: https://doi.org/10.1038/s42003-022-03916-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

The physiological role of Vsp in zebrafish is assessed, revealing Vsp expression in the mid-intestine for dietary protein absorption. A comparative study on marine invertebrate Ciona intestinalis suggests conservation of Vsp function in the GI tract.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal