Journal of Advanced Pharmaceutical Technology & Research (Jan 2010)

Synthesis and biological evaluation of formazan derivatives

  • Gurusamy Mariappan,
  • Rejaul Korim,
  • Nand Madhwa Joshi,
  • Faruk Alam,
  • Rajib Hazarika,
  • Deepak Kumar,
  • Tiewlasubon Uriah

DOI
https://doi.org/10.4103/0110-5558.76438
Journal volume & issue
Vol. 1, no. 4
pp. 396 – 400

Abstract

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The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, 1 H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. All the compounds showed remarkable antibacterial activity at 250 μg/ml, but FM4 and FM3 did not show any inhibition on Staphylococcus aureus and Vibriocholera, respectively. All the compounds showed significant anticonvulsant effect at 100 mg/kg p.o. and the experimental data were statistically significant at P<0.001 level. But none of the compounds was effective against Japanese encephalitis virus.

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