Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling

• Risto O. Juvonen,
• Mira Ahinko,
• Elmeri M. Jokinen,
• Juhani Huuskonen,
• Hannu Raunio,
• Olli T. Pentikäinen

Affiliations

Risto O. Juvonen

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland

Mira Ahinko

Department of Biological and Environmental Science & Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland

Elmeri M. Jokinen

Institute of Biomedicine, Faculty of Medicine, Integrative Physiology and Pharmacology, University of Turku, Turku, Finland

Juhani Huuskonen

Department of Chemistry, University of Jyvaskyla, Jyvaskyla, Finland

Hannu Raunio

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland

Olli T. Pentikäinen

Department of Biological and Environmental Science & Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland