Nature Communications (Feb 2020)
Pathway and network analysis of more than 2500 whole cancer genomes
- Matthew A. Reyna,
- David Haan,
- Marta Paczkowska,
- Lieven P. C. Verbeke,
- Miguel Vazquez,
- Abdullah Kahraman,
- Sergio Pulido-Tamayo,
- Jonathan Barenboim,
- Lina Wadi,
- Priyanka Dhingra,
- Raunak Shrestha,
- Gad Getz,
- Michael S. Lawrence,
- Jakob Skou Pedersen,
- Mark A. Rubin,
- David A. Wheeler,
- Søren Brunak,
- Jose M. G. Izarzugaza,
- Ekta Khurana,
- Kathleen Marchal,
- Christian von Mering,
- S. Cenk Sahinalp,
- Alfonso Valencia,
- PCAWG Drivers and Functional Interpretation Working Group,
- Jüri Reimand,
- Joshua M. Stuart,
- Benjamin J. Raphael,
- PCAWG Consortium
Affiliations
- Matthew A. Reyna
- Department of Computer Science, Princeton University
- David Haan
- Department of Biomolecular Engineering and UC Santa Cruz Genomics Institute, University of California, Santa Cruz
- Marta Paczkowska
- Computational Biology Program, Ontario Institute for Cancer Research, Toronto
- Lieven P. C. Verbeke
- Department of Information Technology, IDLab, Ghent University, IMEC
- Miguel Vazquez
- Barcelona Supercomputing Center (BSC)
- Abdullah Kahraman
- Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich
- Sergio Pulido-Tamayo
- Department of Information Technology, IDLab, Ghent University, IMEC
- Jonathan Barenboim
- Computational Biology Program, Ontario Institute for Cancer Research, Toronto
- Lina Wadi
- Computational Biology Program, Ontario Institute for Cancer Research, Toronto
- Priyanka Dhingra
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Raunak Shrestha
- Vancouver Prostate Centre
- Gad Getz
- The Broad Institute of MIT and Harvard
- Michael S. Lawrence
- The Broad Institute of MIT and Harvard
- Jakob Skou Pedersen
- Department of Molecular Medicine (MOMA), Aarhus University Hospital
- Mark A. Rubin
- Department of Physiology and Biophysics, Weill Cornell Medicine
- David A. Wheeler
- Human Genome Sequencing Center, Baylor College of Medicine
- Søren Brunak
- DTU Bioinformatics, Department of Bio and Health Informatics, Technical University of Denmark, Kemitorvet
- Jose M. G. Izarzugaza
- DTU Bioinformatics, Department of Bio and Health Informatics, Technical University of Denmark, Kemitorvet
- Ekta Khurana
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Kathleen Marchal
- Department of Information Technology, IDLab, Ghent University, IMEC
- Christian von Mering
- Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich
- S. Cenk Sahinalp
- Vancouver Prostate Centre
- Alfonso Valencia
- Barcelona Supercomputing Center (BSC)
- PCAWG Drivers and Functional Interpretation Working Group
- Jüri Reimand
- Computational Biology Program, Ontario Institute for Cancer Research, Toronto
- Joshua M. Stuart
- Department of Biomolecular Engineering and UC Santa Cruz Genomics Institute, University of California, Santa Cruz
- Benjamin J. Raphael
- Department of Computer Science, Princeton University
- PCAWG Consortium
- DOI
- https://doi.org/10.1038/s41467-020-14367-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.
