Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

Satoshi Deyama; Kento Shimoda; Hiroyuki Ikeda; Hayato Fukuda; Satoshi Shuto; Masabumi Minami

doi:10.1016/j.jphs.2018.09.006

Journal of Pharmacological Sciences (Sep 2018)

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

Satoshi Deyama,
Kento Shimoda,
Hiroyuki Ikeda,
Hayato Fukuda,
Satoshi Shuto,
Masabumi Minami

Affiliations

Satoshi Deyama: Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan; Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan
Kento Shimoda: Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan
Hiroyuki Ikeda: Laboratory of Organic Chemistry for Drug Development, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan
Hayato Fukuda: Laboratory of Organic Chemistry for Drug Development, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan
Satoshi Shuto: Laboratory of Organic Chemistry for Drug Development, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan
Masabumi Minami: Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan; Corresponding author. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan. Fax: +81 11 706 4987.

DOI: https://doi.org/10.1016/j.jphs.2018.09.006
Journal volume & issue: Vol. 138, no. 1
pp. 86 – 88

Abstract

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Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS (0.8 mg/kg, i.p.) significantly increased immobility time on the tail suspension test, and this depression-like behavior was dose-dependently attenuated by intracerebroventricular infusion of RvE3 (10 or 100 ng). No effects of LPS or intracerebroventricular infusion of RvE3 on locomotor activity were observed. These results indicate that RvE3, as well as RvE1 and RvE2, have antidepressant effects. Keywords: Antidepressant, ω-3 polyunsaturated fatty acid, Resolvin

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/journal-of-pharmacological-sciences

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