PROGNOSTIC ROLE OF LABORATORY AND IMMUNOHISTOCHEMICAL MARKERS IN THE RECURRENCE OF ORAL MUCOSAL SQUAMOUS CELL CARCINOMA

Abstract

Twenty fifty-nine patients with oral mucosal squamous cell carcinoma (a study group) and 50 healthy volunteers (a control group) were followed up. The poor prognosis and occurrence of early recurrences correlated with the simultaneous high level of C-reactive protein (CRP), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA) (and an increase in their values over time), elevated WNC, ACN, and PLT levels, low Caspase-3 expression, high p53 and bcl-2 expression, and the absence of lower Ki-67 expression over time, and the presence of EBV and CMV in tumor tissue. Decreased Ki-67 index at the stages of treatment, high Caspase-3 expression, low bcl-2 and p53 expression, and low CRP, CEA, and SCCA levels, and tumor HPV-positive status were associated with the favorable prognosis of a tumor process.

Keywords

• recurrent oral mucosal squamous cell carcinoma
• prognostic factors
• laboratory parameters
• immunohistochemical markers
• viruse