Nature Communications (Feb 2021)
Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
- Saori Sakaue,
- Etsuro Yamaguchi,
- Yoshikazu Inoue,
- Meiko Takahashi,
- Jun Hirata,
- Ken Suzuki,
- Satoru Ito,
- Toru Arai,
- Masaki Hirose,
- Yoshinori Tanino,
- Takefumi Nikaido,
- Toshio Ichiwata,
- Shinya Ohkouchi,
- Taizou Hirano,
- Toshinori Takada,
- Satoru Miyawaki,
- Shogo Dofuku,
- Yuichi Maeda,
- Takuro Nii,
- Toshihiro Kishikawa,
- Kotaro Ogawa,
- Tatsuo Masuda,
- Kenichi Yamamoto,
- Kyuto Sonehara,
- Ryushi Tazawa,
- Konosuke Morimoto,
- Masahiro Takaki,
- Satoshi Konno,
- Masaru Suzuki,
- Keisuke Tomii,
- Atsushi Nakagawa,
- Tomohiro Handa,
- Kiminobu Tanizawa,
- Haruyuki Ishii,
- Manabu Ishida,
- Toshiyuki Kato,
- Naoya Takeda,
- Koshi Yokomura,
- Takashi Matsui,
- Masaki Watanabe,
- Hiromasa Inoue,
- Kazuyoshi Imaizumi,
- Yasuhiro Goto,
- Hiroshi Kida,
- Tomoyuki Fujisawa,
- Takafumi Suda,
- Takashi Yamada,
- Yasuomi Satake,
- Hidenori Ibata,
- Nobuyuki Hizawa,
- Hideki Mochizuki,
- Atsushi Kumanogoh,
- Fumihiko Matsuda,
- Koh Nakata,
- Tomomitsu Hirota,
- Mayumi Tamari,
- Yukinori Okada
Affiliations
- Saori Sakaue
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Etsuro Yamaguchi
- Division of Respiratory Medicine and Allergology, Department of Internal Medicine, School of Medicine, Aichi Medical University
- Yoshikazu Inoue
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai
- Meiko Takahashi
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Jun Hirata
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Ken Suzuki
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Satoru Ito
- Division of Respiratory Medicine and Allergology, Department of Internal Medicine, School of Medicine, Aichi Medical University
- Toru Arai
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai
- Masaki Hirose
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai
- Yoshinori Tanino
- Department of Pulmonary Medicine, Fukushima Medical University
- Takefumi Nikaido
- Department of Pulmonary Medicine, Fukushima Medical University
- Toshio Ichiwata
- Department Respiratory Medicine, Tokyo Medical University
- Shinya Ohkouchi
- Occupational Health, Graduate School of Medicine, Tohoku University
- Taizou Hirano
- Respiratory Medicine, School of Medicine, Tohoku University
- Toshinori Takada
- Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital
- Satoru Miyawaki
- Department of Neurosurgery, Faculty of Medicine, the University of Tokyo
- Shogo Dofuku
- Department of Neurosurgery, Faculty of Medicine, the University of Tokyo
- Yuichi Maeda
- Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
- Takuro Nii
- Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
- Toshihiro Kishikawa
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Kotaro Ogawa
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Tatsuo Masuda
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Kenichi Yamamoto
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Kyuto Sonehara
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Ryushi Tazawa
- Student Support and Health Administration Organization, Tokyo Medical and Dental University
- Konosuke Morimoto
- Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University
- Masahiro Takaki
- Department of Infectious Diseases, Nagasaki University Hospital, Nagasaki University
- Satoshi Konno
- Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Masaru Suzuki
- Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Keisuke Tomii
- Department of Respiratory Medicine, Kobe City Medical Center General Hospital
- Atsushi Nakagawa
- Department of Respiratory Medicine, Kobe City Medical Center General Hospital
- Tomohiro Handa
- Department of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University
- Kiminobu Tanizawa
- Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
- Haruyuki Ishii
- Department of Respiratory Medicine, Kyorin University
- Manabu Ishida
- Department of Respiratory Medicine, Kyorin University
- Toshiyuki Kato
- Department of Respiratory Medicine and Allergology, Kariya Toyota General Hospital
- Naoya Takeda
- Department of Respiratory Medicine and Allergology, Kariya Toyota General Hospital
- Koshi Yokomura
- Department of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hospital
- Takashi Matsui
- Department of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hospital
- Masaki Watanabe
- Department of Pulmonary Medicine, Graduate School of Medical & Dental Sciences, Kagoshima University
- Hiromasa Inoue
- Department of Pulmonary Medicine, Graduate School of Medical & Dental Sciences, Kagoshima University
- Kazuyoshi Imaizumi
- Department of Respiratory Medicine, Fujita Health University School of Medicine
- Yasuhiro Goto
- Department of Respiratory Medicine, Fujita Health University School of Medicine
- Hiroshi Kida
- Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
- Tomoyuki Fujisawa
- Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
- Takafumi Suda
- Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
- Takashi Yamada
- Department of Respiratory Medicine, Shizuoka City Shizuoka Hospital
- Yasuomi Satake
- Department of Respiratory Medicine, Shizuoka City Shizuoka Hospital
- Hidenori Ibata
- Department of Respiratory Medicine, National Hospital Organization Mie Chuo Medical Center
- Nobuyuki Hizawa
- Department of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba
- Hideki Mochizuki
- Department of Neurology, Osaka University Graduate School of Medicine
- Atsushi Kumanogoh
- Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
- Fumihiko Matsuda
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Koh Nakata
- Division of Advanced Medical Development, Niigata University Medical and Dental Hospital
- Tomomitsu Hirota
- Division of Molecular Genetics, the Jikei University School of Medicine, Research Center for Medical Science
- Mayumi Tamari
- Division of Molecular Genetics, the Jikei University School of Medicine, Research Center for Medical Science
- Yukinori Okada
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-21011-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 6
Abstract
Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting predisposition to abnormal antibody production.
