A Novel Aromatic Iodination Method, with Sodium Periodate Used as the Only Iodinating Reagent

Abstract

Benzene, halobenzenes and some deactivated arenes readily reacted inanhydrous NaIO4/AcOH/Ac2O/concd. H2SO4 mixtures to afford, after quenching withexcess aqueous Na2SO3 solution (a reducing agent), purified iodinated products in 27-88% yields. This novel method of aromatic iodination is simple, fairly effective andenvironmentally safe.

Keywords

• Arenes
• iodoarenes
• aromatic iodination
• sodium periodate
• periodyl organic intermediates.