Scientific Reports (Dec 2023)
Characteristics of patients with COVID-19 who have deteriorating chest X-ray findings within 48 h: a retrospective cohort study
- Tatsuya Kusumoto,
- Shotaro Chubachi,
- Ho Namkoong,
- Hiromu Tanaka,
- Ho Lee,
- Shiro Otake,
- Kensuke Nakagawara,
- Takahiro Fukushima,
- Atsuho Morita,
- Mayuko Watase,
- Takanori Asakura,
- Katsunori Masaki,
- Hirofumi Kamata,
- Makoto Ishii,
- Naoki Hasegawa,
- Norihiro Harada,
- Tetsuya Ueda,
- Soichiro Ueda,
- Takashi Ishiguro,
- Ken Arimura,
- Fukuki Saito,
- Takashi Yoshiyama,
- Yasushi Nakano,
- Yoshikazu Mutoh,
- Yusuke Suzuki,
- Ryuya Edahiro,
- Koji Murakami,
- Yasunori Sato,
- Yukinori Okada,
- Ryuji Koike,
- Yuko Kitagawa,
- Katsushi Tokunaga,
- Akinori Kimura,
- Seiya Imoto,
- Satoru Miyano,
- Seishi Ogawa,
- Takanori Kanai,
- Koichi Fukunaga
Affiliations
- Tatsuya Kusumoto
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Shotaro Chubachi
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Ho Namkoong
- Department of Infectious Diseases, Keio University School of Medicine
- Hiromu Tanaka
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Ho Lee
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Shiro Otake
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Kensuke Nakagawara
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Takahiro Fukushima
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Atsuho Morita
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Mayuko Watase
- Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center
- Takanori Asakura
- Department of Pulmonary Medicine, Saitama City Hospital
- Katsunori Masaki
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Hirofumi Kamata
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Makoto Ishii
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- Naoki Hasegawa
- Department of Infectious Diseases, Keio University School of Medicine
- Norihiro Harada
- Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine
- Tetsuya Ueda
- Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital
- Soichiro Ueda
- Department of Internal Medicine, Japan Community Health Care Organization (JCHO), Saitama Medical Center
- Takashi Ishiguro
- Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center
- Ken Arimura
- Department of Respiratory Medicine, Tokyo Women’s Medical University
- Fukuki Saito
- Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center
- Takashi Yoshiyama
- Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association
- Yasushi Nakano
- Department of Internal Medicine, Kawasaki Municipal Ida Hospital
- Yoshikazu Mutoh
- Department of Infectious Diseases, Tosei General Hospital
- Yusuke Suzuki
- Department of Respiratory Medicine, Kitasato University Kitasato Institute Hospital
- Ryuya Edahiro
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Koji Murakami
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Yasunori Sato
- Department of Preventive Medicine and Public Health, Keio University School of Medicine
- Yukinori Okada
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Ryuji Koike
- Medical Innovation Promotion Center, Tokyo Medical and Dental University
- Yuko Kitagawa
- Department of Surgery, Keio University School of Medicine
- Katsushi Tokunaga
- Genome Medical Science Project (Toyama), National Center for Global Health and Medicine
- Akinori Kimura
- Institute of Research, Tokyo Medical and Dental University
- Seiya Imoto
- Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo
- Satoru Miyano
- M&D Data Science Center, Tokyo Medical and Dental University
- Seishi Ogawa
- Department of Pathology and Tumor Biology, Kyoto University
- Takanori Kanai
- Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine
- Koichi Fukunaga
- Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
- DOI
- https://doi.org/10.1038/s41598-023-49340-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Abstract The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with worsening CXR findings during early hospitalization. We retrospectively included 1656 consecutive Japanese patients with COVID-19 recruited through the Japan COVID-19 Task Force. Rapid deterioration of CXR findings was defined as increased pulmonary infiltrates in ≥ 50% of the lung fields within 48 h of admission. Rapid deterioration of CXR findings was an independent risk factor for death, most severe illness, tracheal intubation, and intensive care unit admission. The presence of consolidation on CXR, comorbid cardiovascular and chronic obstructive pulmonary diseases, high body temperature, and increased serum aspartate aminotransferase, potassium, and C-reactive protein levels were independent risk factors for rapid deterioration of CXR findings. Risk variant at the ABO locus (rs529565-C) was associated with rapid deterioration of CXR findings in all patients. This study revealed the clinical features, genetic features, and risk factors associated with rapid deterioration of CXR findings, a poor prognostic factor in patients with COVID-19.
