DYNAMICS OF CLINICAL AND IMMUNOLOGICAL INDICATORS OF ACUTE NON-LYMPHOBLASTIC LEUKEMIA

Abstract

The aim of the study was to study the features of clinical manifestations, immunopathogenesis and mechanisms of metabolic status of lymphocytes in patients with acute non-lymphoblastic leukemia (ONLL). At the stage of primary attack and remission of ONLT, T-cell immunodeficiency develops, at the stage of repeated relapse – combined immunodeficiency with defeat of T- and B-systems of immunity. A feature of ONLL is the depletion of the content of NK cells, which contributes to the progression of the disease and the development of relapse. At all stages of ONLL, a marked decrease in the intensity of intracellular metabolic processes of lymphocytes is observed, mitochondrial transport, glycolysis, and metabolism in the lemon cycle decrease. A feature of the primary attack and remission of ONLL is the reduction of peroxide processes in lymphocytes. With repeated relapse, peroxide processes in lymphocytes are restored, however, intracellular lipid catabolism decreases.

Keywords

• острый миелобластный лейкоз
• иммунитет
• ферменты