Motor and sensory cortical processing of neural oscillatory activities revealed by human swallowing using intracranial electrodes
Hiroaki Hashimoto,
Kazutaka Takahashi,
Seiji Kameda,
Fumiaki Yoshida,
Hitoshi Maezawa,
Satoru Oshino,
Naoki Tani,
Hui Ming Khoo,
Takufumi Yanagisawa,
Toshiki Yoshimine,
Haruhiko Kishima,
Masayuki Hirata
Affiliations
Hiroaki Hashimoto
Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan; Department of Neurosurgery, Otemae Hospital, Chuo-ku Otemae 1-5-34, Osaka, Osaka 540-0008, Japan; Endowed Research Department of Clinical Neuroengineering, Global Center for Medical Engineering and Informatics, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan; Corresponding author
Kazutaka Takahashi
Department of Organismal Biology and Anatomy, The University of Chicago, 1027 E 57th St, Chicago, IL 60637, USA
Seiji Kameda
Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Fumiaki Yoshida
Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan; Department of Anatomy and Physiology, Saga Medical School Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga, Saga 849-8501, Japan
Hitoshi Maezawa
Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Satoru Oshino
Department of Neurosurgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Naoki Tani
Department of Neurosurgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Hui Ming Khoo
Department of Neurosurgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Takufumi Yanagisawa
Department of Neurosurgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Toshiki Yoshimine
Endowed Research Department of Clinical Neuroengineering, Global Center for Medical Engineering and Informatics, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Haruhiko Kishima
Department of Neurosurgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan
Masayuki Hirata
Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan; Endowed Research Department of Clinical Neuroengineering, Global Center for Medical Engineering and Informatics, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan; Department of Neurosurgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan; Corresponding author
Summary: Swallowing is attributed to the orchestration of motor output and sensory input. We hypothesized that swallowing can illustrate differences between motor and sensory neural processing. Eight epileptic participants fitted with intracranial electrodes over the orofacial cortex were asked to swallow a water bolus. Mouth opening and swallowing were treated as motor tasks, whereas water injection was treated as a sensory task. Phase-amplitude coupling between lower-frequency and high γ (HG) bands (75–150 Hz) was investigated. An α (10–16 Hz)-HG coupling appeared before motor-related HG power increases (burst), and a θ (5–9 Hz)-HG coupling appeared during sensory-related HG bursts. The peaks of motor-related coupling were 0.6–0.7 s earlier than that of HG power. The motor-related HG was modulated at the trough of the α oscillation, and the sensory-related HG amplitude was modulated at the peak of the θ oscillation. These contrasting results can help to elucidate the brain's sensory motor functions.
