Correlation of Transrectal Ultrasonography Guided Prostate Biopsy Gleason Score Results with Prostate Volume in Patients with Prostate Specific Antigen Level Between 2.5-10 ng/mL

Abstract

Objective: To investigate the correlation between prostate volume (PV) and Gleason score (GS) results obtained by systematic transrectal prostate biopsy in patients with a prostate-specific antigen value between 2.5 and 10 ng/mL. Materials and Methods: A total of 904 patients who underwent transrectal prostate biopsy at our institution were divided into four groups based on PV calculated by transrectal ultrasonography. Group 1 had a PV ≤35 cc, group 2 had a PV ranging from 36 to 55 cc, group 3 had a PV between 56 and 75 cc, and group 4 had a PV >75 cc. Subgroups were based on biopsy-proven prostate carcinoma patients within each group in the same PV intervals, and prostate cancer detection rates and GSs were calculated for each group and subgroup. Results: The prostate cancer detection rate was 78.5% in group 1 and decreased to 17.2% in group 4. GS ≥8 also decreased from 16.4% in group 1 to 2.5% in group 4. However, there was no statistically significant difference between GS ≥8 in the subgroups, with the results of 20.9% in group 1a and 15% in group 4a. Conclusion: Our study results suggest an inverse relationship between PV and cancer detection rates. Although GS ≤6 rates in biopsy-proven prostate carcinoma patients increased and GS of 7 decreased in larger prostates, it was not obvious in patients with GS ≥8. Further prospective studies with large volumes of patients are required to confirm our results.

Keywords

• general urology
• pathology
• urooncology