Simultaneously enhancing the photocatalytic and photothermal effect of NH2-MIL-125-GO-Pt ternary heterojunction for rapid therapy of bacteria-infected wounds

Yue Luo; Bo Li; Xiangmei Liu; Yufeng Zheng; Erjing Wang; Zhaoyang Li; Zhenduo Cui; Yanqin Liang; Shengli Zhu; Shuilin Wu

Bioactive Materials (Dec 2022)

Simultaneously enhancing the photocatalytic and photothermal effect of NH2-MIL-125-GO-Pt ternary heterojunction for rapid therapy of bacteria-infected wounds

Yue Luo,
Bo Li,
Xiangmei Liu,
Yufeng Zheng,
Erjing Wang,
Zhaoyang Li,
Zhenduo Cui,
Yanqin Liang,
Shengli Zhu,
Shuilin Wu

Affiliations

Yue Luo: Biomedical Materials Engineering Research Center, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed By the Province and Ministry, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China
Bo Li: Biomedical Materials Engineering Research Center, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed By the Province and Ministry, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China
Xiangmei Liu: Biomedical Materials Engineering Research Center, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed By the Province and Ministry, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China; School of Life Science and Health Engineering, Hebei University of Technology, Tianjin, 300401, China; Corresponding author. Biomedical Materials Engineering Research Center, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.
Yufeng Zheng: School of Materials Science and Engineering, Peking University, Beijing, 100871, China
Erjing Wang: Biomedical Materials Engineering Research Center, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed By the Province and Ministry, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China; Corresponding author.
Zhaoyang Li: School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China, Tianjin University, Tianjin, 300072, China
Zhenduo Cui: School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China, Tianjin University, Tianjin, 300072, China
Yanqin Liang: School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China, Tianjin University, Tianjin, 300072, China
Shengli Zhu: School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China, Tianjin University, Tianjin, 300072, China
Shuilin Wu: School of Materials Science and Engineering, Peking University, Beijing, 100871, China; Corresponding author.

Journal volume & issue: Vol. 18
pp. 421 – 432

Abstract

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Infections caused by bacteria threaten human health, so how to effectively kill bacteria is an urgent problem. We therefore synthesized a NH2-MIL-125-GO-Pt ternary composite heterojunction with graphene oxide (GO) and platinum (Pt) nanoparticles co-doped with metal-organic framework (NH2-MIL-125) for use in photocatalytic and photothermal synergistic disinfection under white light irradiation. Due to the good conductivity of GO and the Schottky junction between Pt and MOF, the doping of GO and Pt will effectively separate and transfer the photogenerated electron-hole pairs generated by NH2-MIL-125, thereby effectively improving the photocatalytic efficiency of NH2-MIL-125. Meanwhile, NH2-MIL-125-GO-Pt has good photothermal effect under white light irradiation. Therefore, the NH2-MIL-125-GO-Pt composite can be used for effective sterilization. The antibacterial efficiency of NH2-MIL-125-GO-Pt against Staphylococcus aureus and Escherichia coli were as high as 99.94% and 99.12%, respectively, within 20 min of white light irradiation. In vivo experiments showed that NH2-MIL-125-GO-Pt could effectively kill bacteria and promote wound healing. This work brings new insights into the use of NH2-MIL-125-based photocatalyst materials for rapid disinfection of environments with pathogenic microorganisms.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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