PLoS ONE (Jan 2020)

Incidence of hospitalization and mortality due to stroke in young adults, residents of developed regions in Brazil, 2008-2018.

  • Henrique de Moraes Bernal,
  • Luiz Carlos de Abreu,
  • Italla Maria Pinheiro Bezerra,
  • Fernando Adami,
  • Jessica Miwa Takasu,
  • João Victor Ji Young Suh,
  • Silmara de Lira Ribeiro,
  • Edige Felipe de Sousa Santos

DOI
https://doi.org/10.1371/journal.pone.0242248
Journal volume & issue
Vol. 15, no. 11
p. e0242248

Abstract

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IntroductionWe evaluated trends in hospitalization incidence and mortality due to hemorrhagic and ischemic stroke in young adults, according to gender and developed regions in Brazil.MethodsBetween 2008-2018, we performed a population-based time-series study using official hospitalization and death data due to stroke, in individuals aged 10-49 years, from Southeast and South, Brazil. Data were based on reports from the Unified Health System of Hospital Information System and Mortality Information System. Stroke was defined by the International Classification of Diseases, 10th revision (I60-I63). A Prais-Winsten regression model was performed and the Annual Percentage Change was calculated.ResultsIn total, 78,123 hospitalizations of individuals aged 10-49 years were recorded, of which 59,448 (76%) resulted from hemorrhagic stroke (HS). The hospitalizations for HS was significantly decreased (- 4.37%) among men and women in both regions. The hospitalizations for ischemic stroke (IS) was flat, except between 2011 and 2018, when IS hospitalization rates increased. In the analysis by states, HS hospitalizations declined across all states, except for Espírito Santo, where it remained unchanged (p > 0.05). IS flat hospitalizations were observed in all states, except Espírito Santo, where it increased by 24.93%. In terms of mortality, 28,625 deaths were recorded, of which 26,548 (92.7%) resulted from HS. HS mortality decreased significantly by -3.48%and IS mortality by -3.84%. Decreases also occurred in all Southeast and South states (p ConclusionsWe identified a decline in the hospitalizations and mortality of HS and a flat trend for IS in developed regions of Brazil. The recent period (2011-2018) demonstrated increasing rates in the hospitalizations of IS in both regions and genders. The mortality rates for HS and IS decreased between 2008-2018 in Southeast and South Brazil for both genders.