Maternal serum pregnancy-associated plasma protein-A concentration at 11–14 weeks of gestation of women with common congenital anatomic uterine abnormalities

Sotirios Sotiriou; Maria Satra; Dimitra N. Vamvakopoulou; Chrisostomos Sofoudis; Aikaterini Simou; Thomas Kilindris; Andreas Sidiropoulos; Konstantinos V. Kakavas; Antonis Garas; Hara Skentou; Nikos C. Vamvakopoulos; Alexandros Daponte

doi:10.31083/j.ceog.2021.02.2319

Clinical and Experimental Obstetrics & Gynecology (Apr 2021)

Maternal serum pregnancy-associated plasma protein-A concentration at 11–14 weeks of gestation of women with common congenital anatomic uterine abnormalities

Sotirios Sotiriou,
Maria Satra,
Dimitra N. Vamvakopoulou,
Chrisostomos Sofoudis,
Aikaterini Simou,
Thomas Kilindris,
Andreas Sidiropoulos,
Konstantinos V. Kakavas,
Antonis Garas,
Hara Skentou,
Nikos C. Vamvakopoulos,
Alexandros Daponte

Affiliations

Sotirios Sotiriou: Laboratory of Histology and Embryology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Maria Satra: Laboratory of Biology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Dimitra N. Vamvakopoulou: Department of Pediatrics and Neonatology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Chrisostomos Sofoudis: Deptartment of Obstetrics and Gynecology, Konstandopoulio General Hospital, GR-11472 Athens, Greece
Aikaterini Simou: Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Thomas Kilindris: Laboratory of Medical Informatics, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Andreas Sidiropoulos: Laboratory of Biology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Konstantinos V. Kakavas: Laboratory of Environmental quality and human health, Department of Environment, University of Thessaly, GR-41500 Larissa, Greece
Antonis Garas: Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Hara Skentou: Laboratory of Histology and Embryology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Nikos C. Vamvakopoulos: Laboratory of Biology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece
Alexandros Daponte: Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece

DOI: https://doi.org/10.31083/j.ceog.2021.02.2319
Journal volume & issue: Vol. 48, no. 2
pp. 343 – 346

Abstract

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Objectives: To evaluate maternal serum pregnancy-associated plasma protein-A (PAPP-A) levels at 11–14 weeks of gestation in women with common congenital anatomic uterine abnormalities (AUAs). Methods: First trimester screening markers were compared between 12 AUA pregnancies and 60 age matched controls. Results: PAPP-A level and birth weight were significantly lower in AUA compared to control pregnancies (P < 0.001). Conclusion: Our findings suggest that AUA pregnancies are associated with low first trimester maternal serum PAPP-A concentrations.

Published in Clinical and Experimental Obstetrics & Gynecology

ISSN: 0390-6663 (Print); 2709-0094 (Online)
Publisher: IMR Press
Country of publisher: Hong Kong
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://www.imrpress.com/journal/CEOG

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