INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE

Abstract

Objective To investigate the influencing factors for serum 25-(OH)D level in very preterm infants at 4 weeks of age. Methods A total of 158 very preterm infants who were admitted to the neonatal intensive care unit of Qingdao Women and Children’s Hospital from January 2020 to October 2021 were enrolled, and according to the serum 25-(OH)D level at 4 weeks of age, they were divided into sufficient group(≥75 nmol/L) and insufficient group (<75 nmol/L). The two groups were compared in terms of the general data of very preterm infants, maternal data, treatment measures, and complications, and the Logistic regression model was used to investigate the influencing factors for serum 25-(OH)D level in very preterm infants. Results Among the 158 very preterm infants, 72(45.6%) had a serum 25-(OH)D level of ≥75 nmol/L at 4 weeks of age and 86 (54.4%) had a serum 25-(OH)D level of <75 nmol/L. The multivariate analysis showed that birth in winter and spring (OR=4.900,P<0.05) and maternal gestational diabetes mellitus (OR=3.591,P<0.05) were independent influencing factors for serum 25-(OH)D level in very preterm infants at 4 weeks of age. Serum 25-(OH)D level in very preterm infants at 4 weeks of age was associated with the duration of intravenous vitamin D supplementation during hospitalization (OR=0.938,P<0.05). Conclusion There is a re-latively high incidence rate of vitamin D deficiency in very preterm infants at 4 weeks of age, and supplementation with vitamin D should begin as early as possible after birth. For very preterm infants with risk factors for vitamin D deficiency, vitamin D level should be monitored regularly and individualized vitamin D supplementation should be performed.

Keywords

• 25-hydroxyvitamin d|infant, premature|risk factors|time of birth|diabetes, gestational