Parotid gland MALT lymphoma with amyloid deposition, challenges in preoperative diagnosis: A case report

Yuriko Watanabe, MD; Hiroyuki Fujii, MD, PhD; Saki Yamamoto, MD; Sota Masuoka, MD; Ryoma Kobayashi, MD; Nana Fujii, MD; Akihiro Nakamata, MD; Takeharu Kanazawa, MD, PhD; Mitsuru Matsuki, MD, PhD; Harushi Mori, MD, PhD

Radiology Case Reports (Dec 2024)

Parotid gland MALT lymphoma with amyloid deposition, challenges in preoperative diagnosis: A case report

Yuriko Watanabe, MD,
Hiroyuki Fujii, MD, PhD,
Saki Yamamoto, MD,
Sota Masuoka, MD,
Ryoma Kobayashi, MD,
Nana Fujii, MD,
Akihiro Nakamata, MD,
Takeharu Kanazawa, MD, PhD,
Mitsuru Matsuki, MD, PhD,
Harushi Mori, MD, PhD

Affiliations

Yuriko Watanabe, MD: Department of Radiology, Jichi Medical University, Tochigi, Japan
Hiroyuki Fujii, MD, PhD: Department of Radiology, Jichi Medical University, Tochigi, Japan; Corresponding author.
Saki Yamamoto, MD: Department of Radiology, Jichi Medical University, Tochigi, Japan
Sota Masuoka, MD: Department of Radiology, Jichi Medical University, Tochigi, Japan
Ryoma Kobayashi, MD: Department of Radiology, Jichi Medical University, Tochigi, Japan
Nana Fujii, MD: Department of Radiology, Jichi Medical University, Tochigi, Japan
Akihiro Nakamata, MD: Department of Radiology, Jichi Medical University, Tochigi, Japan
Takeharu Kanazawa, MD, PhD: Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, Tochigi, Japan
Mitsuru Matsuki, MD, PhD: Department of Pediatric Radiology, Jichi Children's Medical Center, Tochigi, Japan
Harushi Mori, MD, PhD: Department of Radiology, Jichi Medical University, Tochigi, Japan

Journal volume & issue: Vol. 19, no. 12
pp. 6141 – 6146

Abstract

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Mucosa-associated lymphoid tissue (MALT) lymphoma commonly arises from chronic inflammation or autoimmune diseases, such as Sjögren syndrome (SjS). Although rare, amyloid deposition in MALT lymphoma has been reported. We present a rare case of parotid gland MALT lymphoma in a 49-year-old woman, in whom preoperative diagnosis was challenging due to atypical imaging findings resulting from amyloid deposits. MRI showed T2-hypointense and T1-iso- to slightly hyperintense masses in the left parotid gland and right sublingual gland, with predominant marginal contrast enhancement and no significant diffusion restriction. Additionally, atrophy and fatty replacement of the parenchyma were noted in bilateral parotid glands, suggesting SjS. Left superficial parotidectomy was performed and pathological findings confirmed MALT lymphoma with extensive amyloid deposition. Histopathological findings of the resected parotid gland parenchyma also suggested SjS. MALT lymphoma should be considered in the differential diagnosis of multiple salivary gland masses in patients with suspected SjS. If MRI reveals atypical imaging findings for malignant lymphoma, particularly T2-hypointensity with no significant diffusion restriction, the possibility of amyloid deposition in MALT lymphoma should be considered.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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